Nimotuzumab(Trade name:Tai Xinsheng®)
Nimotuzumab(Trade name:Tai Xinsheng®)
——Anti-EGFR humanized monoclonal antibody
In the 1970s, scientists found out that monoclonal antibodies can specifically target tumor cells, which triggered significant changes in cancer treatment since then. BPL has focused on the clinical application of monoclonal antibodies to treat patients with cancer since 1999, and developed China’s first humanized monoclonal antibody Nimotuzumab (Tai Xin Sheng), which was approved to treat patients with nasopharyngeal cancer in China and put into market in 2008. Nimotuzumab targets epidermal growth factor receptor (EGFR), and is believed to be candidate for the treatment of multiple solid tumors, concerning EGFR participates in the occurrence and development of various malignant tumors by leading to cell proliferation and apoptosis.
According to various clinical trials of Nimotuzumab, it demonstrates great efficacy in treating patients with head and neck cancer, pancreatic cancer, breast cancer, gliomas, NSCLC and so on, and significantly improve the quality of life of patients and extent their life cycle. Now clinical trials of Nimotuzumab along with/without chemotherapy and radiotherapy to treat patients with H&N cancer, esophageal cancer, pancreatic cancer, high-grade pediatric gliomas are under going.
What distinguishes Nimotuzumab from other antibodies is its outstanding safety profile, which has been confirmed by tens of thousands of patients at home and abroad. It is widely agreed that Nimotuzumab can protect normal cells while killing tumor cells, which results in the strong specificity and high bioavailability. Therefore, Nimotuzumab has been successfully recorded into the national medical insurance catalogue in 2017, 2019 and 2021, which enables more cancer patients can benefit from its use.
Biotech pharmaceutical co., Ltd
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